Research progress of engineered mesenchymal stem cells and their derived exosomes and their application in autoimmune/inflammatory diseases.
Xueqing ZhuDan MaBaoqi YangQi AnJingwen ZhaoXinnan GaoLiyun ZhangPublished in: Stem cell research & therapy (2023)
Autoimmune/inflammatory diseases affect many people and are an important cause of global incidence and mortality. Mesenchymal stem cells (MSCs) have low immunogenicity, immune regulation, multidifferentiation and other biological characteristics, play an important role in tissue repair and immune regulation and are widely used in the research and treatment of autoimmune/inflammatory diseases. In addition, MSCs can secrete extracellular vesicles with lipid bilayer structures under resting or activated conditions, including exosomes, microparticles and apoptotic bodies. Among them, exosomes, as the most important component of extracellular vesicles, can function as parent MSCs. Although MSCs and their exosomes have the characteristics of immune regulation and homing, engineering these cells or vesicles through various technical means, such as genetic engineering, surface modification and tissue engineering, can further improve their homing and other congenital characteristics, make them specifically target specific tissues or organs, and improve their therapeutic effect. This article reviews the advanced technology of engineering MSCs or MSC-derived exosomes and its application in some autoimmune/inflammatory diseases by searching the literature published in recent years at home and abroad.
Keyphrases
- mesenchymal stem cells
- umbilical cord
- bone marrow
- multiple sclerosis
- oxidative stress
- tissue engineering
- cell therapy
- induced apoptosis
- systematic review
- risk factors
- type diabetes
- drug induced
- gene expression
- cardiovascular disease
- cell death
- cell cycle arrest
- blood pressure
- cell proliferation
- heart rate variability
- dna methylation