Methionine Commits Cells to Differentiate Into Plasmablasts Through Epigenetic Regulation of BTB and CNC Homolog 2 by the Methyltransferase EZH2.
Mingzeng ZhangShigeru IwataMaiko HajimeNaoaki OhkuboYasuyuki TodorokiHiroko MiyataMasanobu UenoHe HaoTong ZhangJie FanShingo NakayamadaKaoru YamagataYoshiya TanakaPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2020)
Our findings show that methionine activated signaling by controlling immunologic metabolism in B cells and played an important role in the differentiation of B cells into plasmablasts through epigenome modification of Bach2 by the methyltransferase EZH2.