Comprehensive Profiling of Poor-Risk Paired Primary and Recurrent Triple-Negative Breast Cancers Reveals Immune Phenotype Shifts.
Katherine E HutchinsonSusan E YostChing-Wei ChangRadia Marie JohnsonAdrian R CarrPaul R McAdamDaniel L HalliganChun-Chieh ChangDaniel SchmolzeJackson LiangYuan YuanPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
We observed few mutational shifts, but largely consistent transcriptomic shifts in longitudinally paired TNBCs. Transcriptomic and IHC analyses revealed significantly reduced immune-activating gene expression signatures and TILs in recurrent TNBCs. These data may explain the observed lack of efficacy of immunotherapeutic agents in heavily pretreated TNBCs. Further studies are ongoing to better understand these initial observations.See related commentary by Savas and Loi, p. 526.