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Evaluation of combined effect of hyperthermia and ionizing radiation on cytotoxic damages induced by IUdR-loaded PCL-PEG-coated magnetic nanoparticles in spheroid culture of U87MG glioblastoma cell line.

Parisa RezaieSamideh KhoeiSepideh KhoeeSakine ShirvalilouSeied Rabi Mahdavi
Published in: International journal of radiation biology (2018)
According to this study, PCL-PEG-coated magnetic nanoparticles are effective delivery vehicles for IUdR into cells. Moreover, they can act as a radiosensitizer and thermosensitizer in the treatment of the glioblastoma cell line.
Keyphrases
  • magnetic nanoparticles
  • drug delivery
  • induced apoptosis
  • cell cycle arrest
  • cancer therapy
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death