Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress.

Weiwei ShengGuosen WangJingtong TangXiaoyang ShiRongxian CaoJian SunYi Heng LinChao JiaChuanping ChenJianping ZhouMing Dong

Published in: Journal of experimental & clinical cancer research : CR (2020)

CRT promotes EMT in PC via mediating intracellular free Ca2+ dependent TG-induced acute ERS and IRE1α-mediated chronic ERS via Slug and ERK/MAPK signaling.

Keyphrases

endoplasmic reticulum stress
epithelial mesenchymal transition
signaling pathway
induced apoptosis
pi k akt
drug induced
liver failure
cell proliferation
oxidative stress
reactive oxygen species
aortic dissection
acute respiratory distress syndrome