Gestational hypoxia in late pregnancy differentially programs subcortical brain maturation in male and female rat offspring.
E Nicole WilsonSteve MabryJessica L BradshawJennifer J GardnerNataliya RybalchenkoRachel EngellandOluwadarasimi FadeyibiOluwatobiloba OsikoyaSpencer C CushenStyliani GoulopoulouRebecca L CunninghamPublished in: Biology of sex differences (2022)
These novel findings demonstrate hypoxic insults during pregnancy mediate developmental programming of the cortical and subcortical pathways, in which male offspring exhibit long-term adverse effects compared to female offspring. Impairment of cortical and subcortical pathways maturation, such as the nigrostriatal pathway, may increase risk for neuropsychiatric disorders (e.g., mood disorders, cognitive dysfunction, brain connectivity dysfunction).
Keyphrases
- white matter
- high fat diet
- resting state
- multiple sclerosis
- functional connectivity
- oxidative stress
- weight gain
- pregnancy outcomes
- pregnant women
- bipolar disorder
- public health
- insulin resistance
- metabolic syndrome
- preterm birth
- endothelial cells
- body mass index
- sleep quality
- cerebral ischemia
- birth weight
- blood brain barrier