Deoxofluorination of (Hetero)aromatic Acids.
Serhii TrofymchukMaksym Ya BugeraAnton A KlipkovBohdan RazhykSergey SemenovKaren TarasenkoViktoriia S StarovaOlga A ZaporozhetsOksana Yu TananaikoAnatoliy N AlekseenkoYurii PustovitOleksandr KiriakovIgor I GerusAndrei A TolmachevPavel K MykhailiukPublished in: The Journal of organic chemistry (2020)
Diverse trifluoromethyl-substituted compounds were synthesized by deoxofluorination of cinnamic and (hetero)aromatic carboxylic acids with sulfur tetrafluoride. The obtained products were used as starting materials in the preparation of novel fluorinated amino acids, anilines, and aliphatic amines - valuable building blocks for medicinal chemistry and agrochemistry.