Pulmonary Hypertension Induces Serotonin Hyperreactivity and Metabolic Reprogramming in Coronary Arteries via NOX1/4-TRPM2 Signaling Pathway.

Yan-Zhen Huang Ji-Chun Wu Gui-Feng LuHui-Bin LiSu-Mei Lai Yi-Chen LinLong-Xin GuiJames S K Sham Mo-Jun LinDa-Cen Lin

Published in: Hypertension (Dallas, Tex. : 1979) (2024)

PH triggers an increase in 5-hydroxytryptamine reactivity in the right CA and provokes metabolic reprogramming and mitochondrial disruption in CA smooth muscle cells via NOX1/4-TRPM2 activation. This signaling pathway may play an important role in CA remodeling and CA disease in PH.

Keyphrases

signaling pathway
pulmonary hypertension
protein kinase
pi k akt
epithelial mesenchymal transition
coronary artery disease
coronary artery
induced apoptosis
reactive oxygen species
cell proliferation
endoplasmic reticulum stress