Bacterial Dissemination to the Brain in Sepsis.
Benjamin H SingerRobert P DicksonScott J DenstaedtMichael W NewsteadKwi KimNicole R FalkowskiJohn R Erb-DownwardThomas M SchmidtGary B HuffnagleTheodore J StandifordPublished in: American journal of respiratory and critical care medicine (2019)
Although bacterial translocation is associated with acute neuroinflammation in murine sepsis, bacterial translocation did not result in chronic cerebral infection. Postmortem analysis of patients who die of sepsis suggests a role for bacteria in acute brain dysfunction in sepsis. Further work is needed to determine if modifying gut-associated bacterial communities modulates brain dysfunction after sepsis.