Enhanced Hsa-miR-181d/p-STAT3 and Hsa-miR-181d/p-STAT5A Ratios Mediate the Anticancer Effect of Garcinol in STAT3/5A-Addicted Glioblastoma.

Heng-Wei LiuPeter Mingjui LeeOluwaseun Adebayo BamoduYu-Kai SuIat-Hang FongChi-Tai YehMing-Hsien ChienI-Hung KanChien-Min Lin

Published in: Cancers (2019)

We present evidence of anti-GBM efficacy of garcinol mediated by enhancing the hsa-miR-181d/STAT3 and hsa-miR-181d/5A ratios in GBM cells. Our findings suggest a potential new therapeutic agent for combating aggressive GBM.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
pi k akt
induced apoptosis
cell cycle arrest
endoplasmic reticulum stress