DNA methylation alterations in iPSC- and hESC-derived neurons: potential implications for neurological disease modeling.

Laura-Maria de BoniGilles GasparoniCarolin HaubenreichSascha TierlingIna SchmittMichael PeitzPhilipp KochJörn WalterUllrich WüllnerOliver Brüstle

Published in: Clinical epigenetics (2018)

Overall, iPSC-derived neurons exhibit similar DNA methylation patterns compared to isogenic hESC-derived neurons. Further studies will be required to explore whether the epigenetic patterns observed in iPSC-derived neurons correspond to those detectable in native brain neurons.

Keyphrases

dna methylation
spinal cord
gene expression
genome wide
spinal cord injury
risk assessment
brain injury
resting state
subarachnoid hemorrhage
case control