RBM10 loss induces aberrant splicing of cytoskeletal and extracellular matrix mRNAs and promotes metastatic fitness.
Gnana P KrishnamoorthyAnthony R GloverBrian R UntchNickole Sigcha-CoelloBin XuDina VukelYi LiuVera TiedjeKatherine BermanPrasanna P TamarapuAdrian Acuña-RuizMahesh SaqcenaElisa de StanchinaLaura BoucaiRonald A GhosseinJeffrey A KnaufOmar Abdel-WahabRobert K BradleyJames A FaginPublished in: bioRxiv : the preprint server for biology (2024)
RNA splicing factor mutations are common in cancer but connecting phenotypes to specific misspliced genes has been challenging. We show that RBM10 loss leads to exon inclusions of transcripts regulating ECM-cytoskeletal interactions and RAC1-GTP activation, sufficient to promote metastatic fitness.