Physics-informed sinogram completion for metal artifact reduction in CT imaging.

Objective. Metal artifacts in the computed tomography (CT) imaging are unavoidably adverse to the clinical diagnosis and treatment outcomes. Most metal artifact reduction (MAR) methods easily result in the over-smoothing problem and loss of structure details near the metal implants, especially for these metal implants with irregular elongated shapes. To address this problem, we present the physics-informed sinogram completion (PISC) method for MAR in CT imaging, to reduce metal artifacts and recover more structural textures. Approach. Specifically, the original uncorrected sinogram is firstly completed by the normalized linear interpolation algorithm to reduce metal artifacts. Simultaneously, the uncorrected sinogram is also corrected based on the beam-hardening correction physical model, to recover the latent structure information in metal trajectory region by leveraging the attenuation characteristics of different materials. Both corrected sinograms are fused with the pixel-wise adaptive weights, which are manually designed according to the shape and material information of metal implants. To furtherly reduce artifacts and improve the CT image quality, a post-processing frequency split algorithm is adopted to yield the final corrected CT image after reconstructing the fused sinogram. Main results. We qualitatively and quantitatively evaluated the presented PISC method on two simulated datasets and three real datasets. All results demonstrate that the presented PISC method can effectively correct the metal implants with various shapes and materials, in terms of artifact suppression and structure preservation. Significance. We proposed a sinogram-domain MAR method to compensate for the over-smoothing problem existing in most MAR methods by taking advantage of the physical prior knowledge, which has the potential to improve the performance of the deep learning based MAR approaches.