Growth Differentiation Factor-15 as a Potent Predictor of Long-Term Mortality among Subjects with Osteoarthritis.
Natalie ArnoldMartin RehmGisela BücheleRaphael Simon PeterRolf Erwin BrennerKlaus-Peter GüntherHermann BrennerWolfgang KoenigDietrich RothenbacherPublished in: Journal of clinical medicine (2020)
In subjects with OA, GDF-15 represents a potent predictor of decreased survival over >20 years, independently of conventional CV risk factors, renal, cardiac, and inflammatory biomarkers as well as walking disability, previously associated with increased mortality and lower extremity OA.