Wireless asymmetric umpolung electrosynthesis.
Sara GrecchiBartlomiej BonczakFilippo MalacarneGerardo SalinasRoberto CirilliSerena ArnaboldiPublished in: Chemical communications (Cambridge, England) (2024)
Electroorganic synthesis has become an exciting tool for the asymmetric conversion of pro-chiral compounds. Herein, we introduced a wireless methodology based on bipolar electrochemistry in synergy with the enantioselective capabilities of inherently chiral oligomers to induce an umpolung chirality transfer. This was exemplified by the electro-conversion of a racemic mixture of lansoprazole to an enantio -enriched solution of a single antipode.