Exogenous mitochondrial transplantation improves survival and neurological outcomes after resuscitation from cardiac arrest.

Kei HayashidaRyosuke TakegawaYusuke EndoTai YinRishabh C ChoudharyTomoaki AokiMitsuaki NishikimiAtsushi MuraoEriko NakamuraMuhammad ShoaibCyrus KuschnerSantiago J MiyaraJunhwan KimKoichiro ShinozakiPing WangLance B Becker

Published in: BMC medicine (2023)

MTx performed immediately after resuscitation improved survival and neurological recovery in post-CA rats. These results provide a foundation for future studies to promote the development of MTx as a novel therapeutic strategy to save lives currently lost after CA.

Keyphrases

cardiac arrest
cardiopulmonary resuscitation
free survival
oxidative stress
protein kinase
cerebral ischemia
septic shock
case control
blood brain barrier
brain injury