Effect of quercetin on the pharmacokinetics of selexipag and its active metabolite in beagles.
Shun-Bin LuoEr-Min GuYu-Ao ChenShi-Chen ZhouChen FanRen-Ai XuPublished in: Pharmaceutical biology (2022)
The study indicated that quercetin could inhibit the metabolism of selexipag and ACT-333679 when co-administration. Therefore, the clinical dose of selexipag should be used with caution when co-administered with foods high in quercetin.