Radiosynthesis and characterization of [18F]BS224: a next-generation TSPO PET ligand insensitive to the rs6971 polymorphism.

Sang Hee LeeNunzio DenoraValentino LaquintanaGiuseppe Felice MangiatordiAngela LopedotaAntonio LopalcoAnnalisa CutrignelliMassimo FrancoPietro DelreIn Ho SongHye Won KimSu Bin KimHyun Soo ParkKyungmin KimSeok-Yong LeeHyewon YounByung-Chul LeeSang Eun Kim

Published in: European journal of nuclear medicine and molecular imaging (2021)

Our results suggest that [18F]BS224 may be a promising TSPO ligand to gauge neuroinflammatory disease-related areas in a broad range of patients irrespective of the common rs6971 polymorphism.

Keyphrases

pet imaging
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
computed tomography
prognostic factors
patient reported outcomes
pet ct