Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice.

Guadalupe RodriguezMesut ErenIsabel HaupfearKirsten L ViolaErika N ClineToshio MiyataWilliam L KleinDouglas E VaughanHongxin Dong

Published in: Psychopharmacology (2023)

Our results suggest that PAI-1 inhibition could improve memory function and reduce the accumulation of amyloid levels in APP/PS1 mice. Such effects are more prominent when TM5A15 is administered before advanced AD pathology and memory deficits occur.

Keyphrases

working memory
traumatic brain injury
high fat diet induced
mouse model
wild type
metabolic syndrome