Time-course transcriptome analysis of a double challenge bleomycin-induced lung fibrosis rat model uncovers ECM homoeostasis-related translationally relevant genes.

Martina BonattiVanessa PitozziPaola CarusoSilvia PontisMaria Gloria PittelliCaterina FratiChiara MangiaracinaCostanza Anna Maria LagrastaFederico QuainiSimona CantarellaSimone OttonelloGino VillettiMaurizio CivelliBarbara MontaniniMarcello Trevisani

Published in: BMJ open respiratory research (2023)

The model of lung fibrosis presented in this study lends itself as a valuable tool for preclinical efficacy evaluation of new potential drug candidates. The main finding was the identification of a group of persistently dysregulated genes, mostly related to ECM homoeostasis, which are shared with human IPF.

Keyphrases

bioinformatics analysis
endothelial cells
genome wide
drug induced
high glucose
extracellular matrix
idiopathic pulmonary fibrosis
stem cells
climate change
pulmonary fibrosis
adverse drug