JNK signalling mediates aspects of maternal immune activation: importance of maternal genotype in relation to schizophrenia risk.

Rebecca L OpenshawJaedeok KwonAlison McCollJosef M PenningerJonathan CavanaghJudith A PrattBrian J Morris

Published in: Journal of neuroinflammation (2019)

The results demonstrate JNK signalling as a mediator of MIA effects on the foetus. Since both elevated CXCL10 and supressed CXCL12 compromise developing GABAergic interneurons, the results support maternal immune challenge contributing to schizophrenia-associated neurodevelopmental abnormalities. The influence of Map2k7 on cytokine/chemokine induction converges the genetic and environmental aspects of schizophrenia, and the overt influence of maternal genotype offers an intriguing new insight into modulation of embryonic neurodevelopment by genetic risk.

Keyphrases

bipolar disorder
birth weight
pregnancy outcomes
signaling pathway
cell death
genome wide
induced apoptosis
gestational age
copy number
oxidative stress
human health
weight loss
high density
preterm birth