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A New Strategy for the Rapid Identification and Validation of the Direct Targets of Aconitine-Induced Cardiotoxicity.

Jinxia WeiSimiao FanHongxin YuLexin ShuYu-Bo Li
Published in: Drug design, development and therapy (2021)
We developed a complete set of methods to predict and verify the direct targets of aconitine, and cPLA2 was identified as one. Overall, the novel strategy provides new insights into the discovery of direct targets and the molecular mechanism of toxic components that are found in traditional Chinese medicine.
Keyphrases
  • small molecule
  • high glucose
  • drug induced
  • oxidative stress