Low level laser therapy promotes bone regeneration by coupling angiogenesis and osteogenesis.
Jie BaiLijun LiNi KouYuwen BaiYaoyang ZhangYun LuLu GaoFu WangPublished in: Stem cell research & therapy (2021)
LLLT enhanced vascularized bone regeneration by coupling angiogenesis and osteogenesis. ROS/HIF-1α was necessary for these effects of LLLT. LLLT triggered a ROS-dependent increase of HIF-1α, VEGF, and TGF-β and resulted in subsequent formation of type H vessels and osteogenic differentiation of mesenchymal stem cells. As ROS also was a target of HIF-1α, there may be a positive feedback loop between ROS and HIF-1α, which further amplified HIF-1α induction via the LLLT-mediated ROS increase. This study provided new insight into the effects of LLLT on vascularization and bone regeneration in bone tissue engineering.
Keyphrases
- bone regeneration
- endothelial cells
- cell death
- dna damage
- reactive oxygen species
- tissue engineering
- mesenchymal stem cells
- vascular endothelial growth factor
- stem cells
- transcription factor
- body composition
- postmenopausal women
- bone mineral density
- epithelial mesenchymal transition
- transforming growth factor
- soft tissue