Vortioxetine for depression in adults: A systematic review and dose-response meta-analysis of randomized controlled trials.

Xin YangShuping FangWenqi LüYongbo HuHuifang XuXiao JiangYurou ZhaoYuwei ZhangJin LiWeihong Kuang

Published in: Psychiatry and clinical neurosciences (2024)

Vortioxetine may potentially provide additional therapeutic benefits when exceeding the current licensed dosage without significantly impacting safety. Conducting clinical trials exceeding the current approved dosage appears necessary to fully comprehend its efficacy and risk.

Keyphrases

major depressive disorder
clinical trial
systematic review
depressive symptoms
bipolar disorder
sleep quality
physical activity
phase ii
study protocol
drug administration
phase iii