Lung histopathologic clusters in severe COVID-19: a link between clinical picture and tissue damage.

Maddalena Alessandra WuGianluca LopezManuela NebuloniDavide OttolinaJonathan MontomoliLuca CarsanaTommaso FossaliAntonio CastelliRoberto RechChiara CogliatiEmanuele CatenaRiccardo Colombo

Published in: Critical care (London, England) (2021)

Our study draws a comprehensive link between the clinical and pulmonary histopathologic findings in a large cohort of COVID-19 patients. These results highlight that the positive end-expiratory pressures and the duration of the ventilatory treatment correlate with lung histopathologic patterns, providing new clues to the knowledge of the pathophysiology of severe SARS-CoV-2 pneumonia.

Keyphrases

sars cov
respiratory syndrome coronavirus
coronavirus disease
healthcare
early onset
pulmonary hypertension
oxidative stress
intensive care unit
replacement therapy
extracorporeal membrane oxygenation
smoking cessation