Ganoderma lucidum polysaccharides ameliorate lipopolysaccharide-induced acute pneumonia via inhibiting NRP1-mediated inflammation.

Xuelian ZhangDaoshun WuYu TianXiangdong ChenJin LanFei WeiYe LiYun LuoXiaobo Sun

Published in: Pharmaceutical biology (2022)

GLP could protect against LPS-induced acute pneumonia through multiple mechanisms: blocking the infiltration of inflammatory cells, inhibiting cytokine secretion, suppressing NRP1 activation and regulating pneumonocyte apoptosis and autophagy.

Keyphrases

signaling pathway
oxidative stress
induced apoptosis
cell cycle arrest
pi k akt
endoplasmic reticulum stress
cell death
inflammatory response
toll like receptor
lps induced
respiratory failure
community acquired pneumonia
anti inflammatory
immune response