Genomic profiling of radiation-induced sarcomas reveals the immunological characteristics and its response to immune checkpoint blockade.

Dong-Chun Hong Jing Yang Cong Sun Yuan-Tao Liu Lu-Jun Shen Bu-Shu Xu Yi Que Xiaojun Xia Xing Zhang

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Elevated genomic instability and higher immune cell infiltrations was found in RISs than primary sarcomas. Moreover, higher efficacy of chemotherapy plus PD-1 blockade was observed in animal experiment and clinical practice. These evidence indicated the promising application of immune checkpoint inhibitors in the treatment of RISs.

Keyphrases

radiation induced
clinical practice
radiation therapy
high grade
copy number
single cell
locally advanced
smoking cessation
gene expression
dna methylation