MAPK Pathway Genetic Alterations Are Associated with Prolonged Overall Survival in Low-Grade Serous Ovarian Carcinoma.
Beryl L Manning-GeistSushmita GordhandasYing L LiuQin C ZhouAlexia IasonosArnaud Da Cruz PaulaDiana MandelkerKara Long RocheOliver ZivanovicAnna MaioYelena M KemelDennis S ChiRoisin E O'CearbhaillCarol AghajanianJorge S Reis-FilhoMichael Herman ChuiRachel N GrishamPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
This study showed that MAPK pathway alterations in LGSC, including KRAS mutations, are independently associated with platinum sensitivity and prolonged survival. Germline data, which were limited, identified few pathogenic germline mutations in patients with LGSC. See related commentary by Veneziani and Oza, p. 4357.