Abemaciclib Is Active in Preclinical Models of Ewing Sarcoma via Multipronged Regulation of Cell Cycle, DNA Methylation, and Interferon Pathway Signaling.

Michele DowlessCaitlin D LoweryTerry ShacklefordMatthew RenschlerJennifer StephensRobert FlackWayne BlosserSimone GuptaJulie StewartYue WebsterJack DempseyAlle B VanWyePhilip EbertPhilip IversenJonathan B OlsenXueqian GongSean G BuchananPeter HoughtonLouis Stancato

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Collectively, our data demonstrate that the antitumor effects of abemaciclib in preclinical ES models are multifaceted and include cell-cycle inhibition, DNA demethylation, and immunogenic changes.

Keyphrases

cell cycle
dna methylation
cell proliferation
cell therapy
circulating tumor
gene expression
genome wide
electronic health record
dendritic cells
cell free
big data
mesenchymal stem cells
bone marrow
data analysis