Prevalence and characteristics of HIV drug resistance among antiretroviral treatment (ART) experienced adolescents and young adults living with HIV in Ndola, Zambia.
Sam MitiRay HandemaLloyd MulengaJonathan K MwansaElizabeth AbramsChristiana FrimpongVirginia M BurkeMangani ZuluMpanji SiwingwaDavid MwakazangaSam KalibalaJulie A DenisonPublished in: PloS one (2020)
There is a high prevalence of HIVDR including TAMs despite majority of these patients (90.48%) being on AZT or d4T sparing first line ART among the youth. Emergence of these mutations including the NNRTI associated mutations (Y181C and Y188C) may compromise future second- and third-line regimens in the absence of routine HIVDR testing. HIVDR monitoring at start of ART or at first-line failure can better inform clinical decision making and ART programing.
Keyphrases
- hiv infected
- antiretroviral therapy
- human immunodeficiency virus
- hiv positive
- hiv aids
- hiv infected patients
- end stage renal disease
- decision making
- ejection fraction
- chronic kidney disease
- newly diagnosed
- risk factors
- mental health
- peritoneal dialysis
- prognostic factors
- hepatitis c virus
- physical activity
- clinical practice
- patient reported
- hiv testing
- replacement therapy