Genetic deletion of ITIH5 leads to increased development of adipose tissue in mice.

Thomas M SesslerJustus P BeierSophia VillwockDanny JonigkEdgar DahlTim Ruhl

Published in: Biological research (2024)

Our data suggest that ITIH5 potently regulates adipose tissue development and homeostasis by modulating ASC biology in mice. In addition, the effect of the rITIH5 protein underscores its potential as a therapeutic agent to correct the adipose tissue dysregulation often associated with obesity and metabolic disorders.

Keyphrases

adipose tissue
insulin resistance
high fat diet induced
high fat diet
metabolic syndrome
type diabetes
skeletal muscle
genome wide
signaling pathway
physical activity
copy number
weight gain
nlrp inflammasome
protein protein
small molecule
data analysis