Inhibition of Rho-Kinase Downregulates Th17 Cells and Ameliorates Hepatic Fibrosis by Schistosoma japonicum Infection.

Wei ZhouYingying YangCongjin MeiPanpan DongShasha MuHongchu WuYonghua ZhouYi ZhengFukun Guo Jun-Qi Yang

Published in: Cells (2019)

Fasudil inhibits hepatic granuloma formation and fibrosis with downregulation of Th17 cells. Fasudil might serve as a novel therapeutic agent for hepatic fibrosis due to schistosome infections and perhaps other disorders.

Keyphrases

induced apoptosis
cell cycle arrest
signaling pathway
protein kinase
cell proliferation
cell death
tyrosine kinase