Mass spectroscopy-based proteomics and metabolomics analysis of triple-positive breast cancer cells treated with tamoxifen and/or trastuzumab.

Basma M SharafAlexander D GiddeyHamza M Al-HroubVarsha MenonJavan OkendoRaafat El-AwadyMuath MousaAhmed AlmehdiMohammad H SemreenNelson Cruz Soares

Published in: Cancer chemotherapy and pharmacology (2022)

Our findings in protein and metabolite level research revealed that anti-cancer drug therapy had a significant impact on the key signalling pathways and molecular processes in triple positive BT-474 cell lines.

Keyphrases

positive breast cancer
mass spectrometry
induced apoptosis
single molecule
cell cycle arrest
high resolution
epidermal growth factor receptor
single cell
signaling pathway
emergency department
amino acid
solid state
cell therapy
breast cancer cells