Genetically proxied low-density lipoprotein cholesterol lowering via PCSK9-inhibitor drug targets and risk of congenital malformations.

Maddalena ArdissinoEric A W SlobRohin K ReddyAlec P MorleyArt SchuermansPhoebe HillCatherine WilliamsonMichael C HonigbergAntonio de MarvaoFu Siong Ng

Published in: European journal of preventive cardiology (2024)

These data provide genetic evidence supporting current manufacturer advice to avoid the use of PCSK9 inhibitors during pregnancy.

Keyphrases

low density lipoprotein
electronic health record
genome wide
big data
copy number
gene expression
dna methylation
drug induced
artificial intelligence