B Cell Epigenetic Modulation of IgA Response by 5-Azacytidine and IgA Nephropathy.

Shanshan YuXiang LiTing WangJingyi Li Hongzhi LiYing XuYanling HuFubin ZhuJin-Wei WangTianhe WangBin Zhu Xu-Jie ZhouHong ZhangJicheng LvJonathan BarrattBinghai Zhao

Published in: Journal of the American Society of Nephrology : JASN (2024)

This study revealed TRDMT1 induced RNA 5mC methylation regulate IgA class switch and inhibition of RNA 5mC by 5-Azacytidine could ameliorate progression of IgA nephropathy.

Keyphrases

dna methylation
gene expression
genome wide
single cell
nucleic acid