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Development and Validation of the PREMMplus Model for Multigene Hereditary Cancer Risk Assessment.

Matthew B YurgelunHajime UnoC Sloane FurnissChinedu UkaegbuMiki HoriguchiAmal YussufHolly LaDucaAnu ChittendenJudy E GarberSapna Syngal
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2022)
PREMMplus accurately identifies individuals with PGVs in a diverse spectrum of cancer susceptibility genes with high sensitivity/NPV. Individuals with PREMMplus scores ≥ 2.5% should be considered for MGPT.
Keyphrases
  • papillary thyroid
  • risk assessment
  • squamous cell
  • genome wide
  • lymph node metastasis
  • heavy metals
  • transcription factor