Biomarkers of Glycocalyx Injury and Endothelial Activation are Associated with Clinical Outcomes in Patients with Sepsis: A Systematic Review and Meta-Analysis.

Fernández-Sarmiento JaimeCarlos Federico MolinaLina María Salazar-PelaezSteffanie FlórezLaura Carolina Alarcón-ForeroMauricio SartaRicardo Hernández-SarmientoJuan Carlos Villar

Published in: Journal of intensive care medicine (2022)

Patients with sepsis and abnormal glycocalyx injury and endothelial activation biomarkers have a greater risk of developing respiratory failure, multiple organ failure, and death. Microcirculatory impairment should be routinely evaluated in patients with sepsis, using biomarkers to stratify risk groups.

Keyphrases

septic shock
respiratory failure
acute kidney injury
intensive care unit
endothelial cells
mechanical ventilation
extracorporeal membrane oxygenation
acute respiratory distress syndrome