Phase I clinical study of NMB58, a novel positron emission tomography (PET)-myocardial perfusion imaging tracer, conducted to evaluate its safety and pharmacokinetics in Japanese healthy adult males.

Mirai KawanoJunichi TsuchiyaHyeyeol BaeKoichiro KimuraKota YokoyamaMarie TakahashiMakiko HondaMasato TominagaUkihide Tateishi

Published in: Annals of nuclear medicine (2021)

Based on radiation dosimetry, biodistribution, and safety evaluations, NMB58 was found to be a suitable tracer for clinical use in PET myocardial perfusion imaging during exercise or pharmacological stress.

Keyphrases

positron emission tomography
computed tomography
pet imaging
high resolution
pet ct
high intensity
physical activity
resistance training
radiation induced
photodynamic therapy
stress induced
double blind