Coadministered cannabidiol and clobazam: Preclinical evidence for both pharmacodynamic and pharmacokinetic interactions.
Lyndsey L AndersonNathan L AbsalomSarah V AbelevIvan K LowPeter T DoohanLewis J MartinMary ChebibIain S McGregorJonathon C ArnoldPublished in: Epilepsia (2019)
Our study highlights the involvement of both pharmacodynamic and pharmacokinetic interactions between CBD and clobazam that may contribute to its efficacy in Dravet syndrome.
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