The Role and Regulation of Pulmonary Artery Smooth Muscle Cells in Pulmonary Hypertension.
Shixin HeTengteng ZhuZhenfei FangPublished in: International journal of hypertension (2020)
Pulmonary hypertension (PH) is one of the most devastating cardiovascular diseases worldwide and it draws much attention from numerous scientists. As an indispensable part of pulmonary artery, smooth muscle cells are worthy of being carefully investigated. To elucidate the pathogenesis of PH, several theories focusing on pulmonary artery smooth muscle cells (PASMC), such as hyperproliferation, resistance to apoptosis, and cancer theory, have been proposed and widely studied. Here, we tried to summarize the studies, concentrating on the role of PASMC in the development of PH, feasible molecular basis to intervene, and potential treatment to PH.
Keyphrases
- pulmonary artery
- pulmonary hypertension
- pulmonary arterial hypertension
- coronary artery
- cardiovascular disease
- endoplasmic reticulum stress
- papillary thyroid
- cell death
- working memory
- cell cycle arrest
- squamous cell carcinoma
- type diabetes
- metabolic syndrome
- cell proliferation
- mass spectrometry
- cardiovascular risk factors