Endoplasmic reticulum stress leads to mitochondria-mediated apoptosis in cells treated with anti-HIV protease inhibitor ritonavir.
Krishna Kumar GantaBinay ChaubeyPublished in: Cell biology and toxicology (2018)
The cytotoxic effects of ritonavir involved the interplay of ER stress and mitochondria-mediated apoptosis. This unusual mechanism of drug-induced toxicity expands our knowledge in understanding side effects caused by ritonavir.
Keyphrases
- induced apoptosis
- endoplasmic reticulum stress
- antiretroviral therapy
- drug induced
- liver injury
- hiv infected
- hiv positive
- human immunodeficiency virus
- oxidative stress
- hiv aids
- cell death
- signaling pathway
- healthcare
- endoplasmic reticulum
- reactive oxygen species
- cell cycle arrest
- hepatitis c virus
- adverse drug
- hiv testing
- cell proliferation
- newly diagnosed
- men who have sex with men
- oxide nanoparticles