Prevalence of HFE-related haemochromatosis and secondary causes of hyperferritinaemia and their association with iron overload in 1059 French patients treated by venesection.

Gérald Le GacVirginie ScotetIsabelle GourlaouenCarine L'HostisMarie-Christine MerourZoubida KarimYves DeugnierEdouard Bardou-JacquetThibaud LefebvreSuzanne AssariClaude Ferec

Published in: Alimentary pharmacology & therapeutics (2022)

Haemochromatosis is over-diagnosed and is no longer the main reason for therapeutic venesection in France. Obesity and other metabolic abnormalities are frequently associated with mild elevation of serum ferritin, the MetS is confirmed in ~50% of treated patients. There is a minimal relationship between serum ferritin and iron overload in non-p.Cys282Tyr homozygotes. Our observations raise questions about venesection indications in non-haemochromatosis patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
prognostic factors
metabolic syndrome
risk factors
patient reported outcomes
iron deficiency
body mass index
drug induced