Dendritic Cells as a Nexus for the Development of Multiple Sclerosis and Models of Disease.
Nada S AlakhrasMark H KaplanPublished in: Advanced biology (2023)
Multiple sclerosis (MS) results from an autoimmune attack on the central nervous system (CNS). Dysregulated immune cells invade the CNS, causing demyelination, neuronal and axonal damage, and subsequent neurological disorders. Although antigen-specific T cells mediate the immunopathology of MS, innate myeloid cells have essential contributions to CNS tissue damage. Dendritic cells (DCs) are professional antigen-presenting cells (APCs) that promote inflammation and modulate adaptive immune responses. This review focuses on DCs as critical components of CNS inflammation. Here, evidence from studies is summarized with animal models of MS and MS patients that support the critical role of DCs in orchestrating CNS inflammation.
Keyphrases
- multiple sclerosis
- dendritic cells
- immune response
- oxidative stress
- induced apoptosis
- blood brain barrier
- mass spectrometry
- white matter
- ms ms
- cell cycle arrest
- end stage renal disease
- regulatory t cells
- ejection fraction
- toll like receptor
- endoplasmic reticulum stress
- signaling pathway
- bone marrow
- newly diagnosed
- acute myeloid leukemia
- chronic kidney disease
- spinal cord injury
- prognostic factors
- cell death
- pi k akt
- optic nerve
- patient reported