Immunomodulatory Activity of Punicalagin, Punicalin, and Ellagic Acid Differs from the Effect of Pomegranate Peel Extract.
Miodrag ČolićDušan MihajlovićMarina BekićMilan MarkovićBranka DragišićSergej TomićNataša MiljušKatarina ŠavikinRanko ŠkrbićPublished in: Molecules (Basel, Switzerland) (2022)
The combination of PG, PN, and EA potentiated the anti-inflammatory response without any significant synergistic down-modulatory effect on T-cell cytokines. The increased production of IL-10 observed with PEx could be attributable to EA, but the examined ellagitannins are not associated with the stimulatory effect of PEx on Th2 response.