Targeting the polyamine pathway-"a means" to overcome chemoresistance in triple-negative breast cancer.
Colleen A SweeneyPublished in: The Journal of biological chemistry (2020)
Triple-negative breast cancer (TNBC) is characterized by its aggressive biology, early metastatic spread, and poor survival outcomes. TNBC lacks expression of the targetable receptors found in other breast cancer subtypes, mandating use of cytotoxic chemotherapy. However, resistance to chemotherapy is a significant problem, encountered in about two-thirds of TNBC patients, and new strategies are needed to mitigate resistance. In this issue of the Journal of Biological Chemistry, Geck et al. report that TNBC cells are highly sensitive to inhibition of the de novo polyamine synthesis pathway and that inhibition of this pathway sensitizes cells to TNBC-relevant chemotherapy, uncovering new opportunities for addressing chemoresistance.
Keyphrases
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- locally advanced
- endoplasmic reticulum stress
- squamous cell carcinoma
- newly diagnosed
- ejection fraction
- chronic kidney disease
- signaling pathway
- peritoneal dialysis
- prognostic factors
- radiation therapy
- cell death
- cancer therapy
- binding protein
- cell proliferation
- patient reported outcomes
- single molecule
- pi k akt
- label free