Pro-neurotensin depends on renal function and is related to all-cause mortality in chronic kidney disease.
Anke TönjesAnnett HoffmannSusan KralischAbdul Rashid QureshiNora KlötingMarkus ScholzDorit SchleinitzAnette BachmannJürgen KratzschMarcin NowickiSabine PaeschkeKerstin WirknerCornelia EnzenbachRonny BaberJoachim BeigeMatthias AndersIngolf BastMatthias BlüherPeter KovacsMarkus LöfflerMing-Zhi ZhangRaymond C HarrisPeter StenvinkelMichael StumvollMathias FasshauerThomas EbertPublished in: European journal of endocrinology (2020)
Circulating Pro-NT is associated with impaired renal function in independent cohorts comprising 4715 subjects and is related to all-cause mortality in patients with end-stage kidney disease. Our human and rodent data are in accordance with the hypotheses that Pro-NT is eliminated by the kidneys and could potentially contribute to increased mortality observed in patients with CKD.