A New Electrochemical Platform for Dasatinib Anticancer Drug Sensing Using Fe3O4-SWCNTs/Ionic Liquid Paste Sensor.
Ali MoghaddamHassan Ali ZamaniHassan Karimi-MalehPublished in: Micromachines (2021)
A new electrochemical platform was suggested for the sensing of the dasatinib (DA) anticancer drug based on paste electrode modification (PE) amplified with Fe3O4-SWCNTs nanocomposite and 1-hexyl-3-methylimidazolium tetrafluoroborate (mim-BF4-). The new platform showed a linear dynamic range from 0.001-220 µM with a detection limit of 0.7 nM to determine DA at optimal condition. Electrochemical investigation showed that the redox reaction of DA is relative to changing the pH of solution. Moreover, Fe3O4-SWCNTs/mim-BF4-/PE has improved the oxidation current of DA about 5.58 times which reduced its oxidation potential by about 120 mV at optimal condition. In the final step, Fe3O4-SWCNTs/mim-BF4-/PE was used as an analytical platform to determine the DA in tablets and a dextrose saline spike sample, and the results showed recovery data 99.58-103.6% which confirm the powerful ability of the sensor as an analytical tool to determine the DA in real samples.
Keyphrases
- ionic liquid
- molecularly imprinted
- high throughput
- gold nanoparticles
- label free
- room temperature
- electron transfer
- hydrogen peroxide
- electronic health record
- quantum dots
- reduced graphene oxide
- risk assessment
- highly efficient
- single cell
- artificial intelligence
- big data
- real time pcr
- visible light
- mass spectrometry