Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling.

Yinan Jiang Apeng ChenDiana KlineQun LiuJie MaYan WangTing ZhangJieqi QianLaura NelsonKrishna PrasadanBaoli HuGeorge K GittesXiangwei Xiao

Published in: Diabetes, obesity & metabolism (2022)

Our study shows a regulatory loop between macrophages and beta cells through PlGF/EGF/ERK5 signalling cascades to regulate gestational beta cell growth.

Keyphrases

weight gain
transcription factor
pregnant women
induced apoptosis
signaling pathway
cell cycle arrest
birth weight
pregnancy outcomes
pi k akt
growth factor
tyrosine kinase
protein kinase
endoplasmic reticulum stress
physical activity
oxidative stress
cell death
preterm birth