Levetiracetam, lamotrigine and carbamazepine: which monotherapy during pregnancy?
Luisa MariFabio PlacidiAndrea RomigiMario TombiniChiara Del BiancoMartina UliviClaudio LiguoriNatalia ManfrediAlessandro CastelliNicola Biagio MercuriFrancesca IzziPublished in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2021)
A better clinical outcome during pregnancy emerged since the first trimester in comparison to the before-pregnancy period, mostly evident in women with GE and LEV therapy, reinforcing the hypothesis of a protective role of pregnancy versus seizures. SF before pregnancy represents a significant predictive factor of good clinical outcome during gestation and the post-partum period. Compared to CBZ, LTG and LEV showed a better safety profile.