SH2 Domain-Containing Phosphatase-SHP2 Attenuates Fibrotic Responses through Negative Regulation of Mitochondrial Metabolism in Lung Fibroblasts.

Theodoros KarampitsakosApostolos GalarisIlianna BarbayianniGiuseppe DeIuliisFarida AhangariFotis SampsonasVasilina SotiropoulouVassilis AidinisAnton M BennettJose D Herazo-MayaNikolaos XylourgidisBakakos Petros Demosthenes BourosNaftali KaminskiArgyrios Tzouvelekis

Published in: Diagnostics (Basel, Switzerland) (2023)

SHP2 attenuates fibrotic responses in fibroblast cell lines through negative regulation of mitochondrial metabolism and induction of autophagy. SHP2 activation may represent a promising therapeutic strategy for patients with fibrotic lung diseases.

Keyphrases

oxidative stress
systemic sclerosis
idiopathic pulmonary fibrosis
cell death
signaling pathway
protein kinase